Adrenal gland cancer

MedGen UID:: 152909
•Concept ID:: C0750887
•: Neoplastic Process

Synonyms:	Adrenal Cancer; Adrenal Cancers; Adrenal Gland Cancer; Adrenal Gland Cancers; Cancer of the Adrenal Gland; Cancer, Adrenal; Cancer, Adrenal Gland; Cancers, Adrenal; Cancers, Adrenal Gland
SNOMED CT:	CA - Cancer of adrenal gland (363355002); Cancer of adrenal gland (363355002); Adrenal gland malignancy (363355002); Malignant tumor of adrenal gland (363355002)

Monarch Initiative:	MONDO:0002817

Definition

A primary or metastatic malignant neoplasm affecting the adrenal gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdrenal gland cancer

Pathological process
- Disease
  - Disorder by Site
    - Disorder of endocrine system
      - Disorder of adrenal gland
        Neoplasm of the adrenal gland
        Adrenal gland cancer
        Adrenal Gland Lymphoma
        Adrenal Gland Sarcoma
        Adrenal Gland Angiosarcoma
        Adrenal medulla cancer
        Adrenal gland ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Intermixed
        Adrenal Gland Ganglioneuroblastoma, Nodular
        Adrenal gland neuroblastoma
        Malignant adrenal gland pheochromocytoma
        Metastatic Adrenal Gland Composite Pheochromocytoma
        Metastatic carcinoma in the adrenal medulla
        Malignant tumor of adrenal cortex
        Adrenal cortex carcinoma
        Adrenal Cortical Carcinoma by AJCC v7 Stage
        Adrenal Cortical Carcinoma by AJCC v8 Stage
        Adrenal Cortical Low Grade Carcinoma
        Adrenal Cortical Sarcomatoid Carcinoma
        Metastatic Adrenal Cortical Carcinoma
        Recurrent Adrenal Cortical Carcinoma
        Unresectable Adrenal Cortical Carcinoma
        Metastatic Carcinoma in the Adrenal Cortex

Professional guidelines

PubMed

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Pelsma I, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066. PMID: 37318239

Personalized Management of Pheochromocytoma and Paraganglioma.

Nölting S, Bechmann N, Taieb D, Beuschlein F, Fassnacht M, Kroiss M, Eisenhofer G, Grossman A, Pacak K
Endocr Rev 2022 Mar 9;43(2):199-239. doi: 10.1210/endrev/bnab019. PMID: 34147030 Free PMC Article

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

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Recent clinical studies

Etiology

The 15-year national trends of endocrine cancers incidence among Iranian men and women; 2005-2020.

Balajam NZ, Mousavian AH, Sheidaei A, Gohari K, Tavangar SM, Ghanbari-Motlagh A, Ostovar A, Shafiee G, Heshmat R
Sci Rep 2023 May 10;13(1):7632. doi: 10.1038/s41598-023-34155-2. PMID: 37164997 Free PMC Article

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Diagnosis

Highly sensitive label-free biosensor: graphene/CaF(2) multilayer for gas, cancer, virus, and diabetes detection with enhanced quality factor and figure of merit.

Jafari B, Gholizadeh E, Jafari B, Zhoulideh M, Adibnia E, Ghafariasl M, Noori M, Golmohammadi S
Sci Rep 2023 Sep 27;13(1):16184. doi: 10.1038/s41598-023-43480-5. PMID: 37758823 Free PMC Article

The 15-year national trends of endocrine cancers incidence among Iranian men and women; 2005-2020.

Novel Bottom-Side Polished PCF-Based Plasmonic Biosensor for Early Detection of Hazardous Cancerous Cells.

Singh S, Prajapati YK
IEEE Trans Nanobioscience 2023 Jul;22(3):647-654. Epub 2023 Jun 29 doi: 10.1109/TNB.2023.3233990. PMID: 37018257

Cancer cell detection by a heart-shaped dual-core photonic crystal fiber sensor.

Mishra GP, Kumar D, Chaudhary VS, Murmu G
Appl Opt 2020 Nov 20;59(33):10321-10329. doi: 10.1364/AO.409221. PMID: 33361963

A Rare Case of Locally Advanced Primary Small Cell Neuroendocrine Carcinoma of the Adrenal Gland.

Limonnik V, Shah D, Sandhu A, Monga DK
Anticancer Res 2020 Oct;40(10):5933-5938. doi: 10.21873/anticanres.14614. PMID: 32988925

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Therapy

Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements.

Liu L, Yang M, Chen Z
Drug Deliv 2024 Dec;31(1):2390022. Epub 2024 Aug 13 doi: 10.1080/10717544.2024.2390022. PMID: 39138394 Free PMC Article

Adrenal gland: Cancer target of mitotane identified.

Holmes D
Nat Rev Endocrinol 2015 Nov;11(11):631. Epub 2015 Sep 15 doi: 10.1038/nrendo.2015.156. PMID: 26370730

Phase I dose-escalation studies of SNX-5422, an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumours.

Infante JR, Weiss GJ, Jones S, Tibes R, Bauer TM, Bendell JC, Hinson JM Jr, Von Hoff DD, Burris HA 3rd, Orlemans EO, Ramanathan RK
Eur J Cancer 2014 Nov;50(17):2897-904. Epub 2014 Sep 25 doi: 10.1016/j.ejca.2014.07.017. PMID: 25262379

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